Hi Jinchao

Some ideas that might help manage this.

Create groups in the course to place the 100 users in with their facilitator - use the separate groups setting so one group can't see the other.

Use forum activities or other interactive activities to support the learning resources - (keep the numbering system of resources and forum discussions) use separate groups here too.

Have a course area where facilitators can share resources and discuss issues with the course.

Enrolments could be done through csv import including the group id if this is known in advance or otherwise use self enrolment to minimise administration.

Use assignments for uploads and use groups here to so marker allocation is easier.

Use quizzes if possible to automate marking with a question bank that facilitators can contribute to and randomise questions to prevent copying of questions.

Hope this gets you started.

Craig